Source: http://feedproxy.google.com/~r/Techcrunch/~3/MIMHMdzpms0/
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Monday, 16 January 2012
Ooma CEO Eric Stang Shows Off The New HD2 VoIP Handset
At CES 2012, there are quite a few products that would totally change the way you do things (or at least save you some money) that just don't get enough coverage. We reported on Ooma's new HD2 VoIP handset, but nothing beats getting the facts straight from the CEO of the company. Luckily, Eric Stang had a chance to meet with us and chat it up.
Regis Philbin sells Conn. house for $3M (omg!)
GREENWICH, Conn. (AP) ? Television host Regis Philbin and his wife, Joy, have sold one of their Connecticut homes for $3 million.
The Greenwich Time reports (http://bit.ly/ye4QCb ) that town records show the Colonial home in Greenwich was placed on the market for $3.8 million in July and sold for $3 million in September.
The buyer, Raymond LaChance, told the newspaper that the fact that Philbin is the former owner is "kind of neat," but that did not influence his and his wife's decision to purchase the house.
The home has nearly 6,000 square feet of space and sits on six acres near a state park. It also includes a pool, a tennis court and a gazebo.
The Philbins own another home less than two miles away and an apartment in Manhattan.
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Sunday, 15 January 2012
Michelle Obama?s complaints about Jodi Kantor book unjustified (Washington Post)
Software for analyzing digital pathology images proving its usefulness
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Public release date: 13-Jan-2012[ | E-mail |
Share ] Contact: Ian Demsky
idemsky@umich.edu
734-764-2220
University of Michigan Health System
In bladder cancer test case, new software tool developed at U-M separates malignancy from background tissue
As tissue slides are more routinely digitized to aid interpretation, a software program whose design was led by the University of Michigan Health System is proving its utility.
In a new study, a program known as Spatially Invariant Vector Quantization (SIVQ) was able to separate malignancy from background tissue in digital slides of micropapillary urothelial carcinoma, a type of bladder cancer whose features can vary widely from case to case and that presents diagnostic challenges even for experts.
The findings by U-M and Rutgers University researchers were published online in Analytical Cellular Pathology ahead of print publication.
"Being able to pick out cancer from background tissue is a key test for this type of software tool," says U-M informatics fellow Jason Hipp, M.D., Ph.D., who shares lead authorship of the paper with resident Steven Christopher Smith, M.D., Ph.D. "This is the type of validation that has to happen before digital pathology tools can be widely used in a clinical setting."
To test the software's ability to identify cancer in a digital slide, a group of human pathologists first pinpointed the cancer the old fashioned way, by hand. Their work was then used as the gold standard for grading the program's results. Researchers then systematically tested which settings within the program produced the most accurate results which can serve as a blueprint for optimizing the software to detect other types of cancer and disease.
Diagnosing cancer and other pathologies from tissue slides has always been part science and part art. Pathologists pore over samples looking for certain structural anomalies or counting microscopic features.
But different pathologists or even the same pathologist at different times may come to different conclusions based on a number of factors, including whether a slide is viewed at high or low magnification, or even whether the pathologist is fatigued from examining dozens of other slides that day, the researchers say.
Digital tools like SIVQ can help pathologists to quickly, accurately and efficiently identify features on a slide with just a few clicks; to quickly calculate the area of an irregularly shaped feature; or to eliminate the slow and painstaking tallying of tiny elements.
Still, the authors stress, the program isn't intended to replace the skill and art of human pathologists, but to provide an additional resource.
"Not only do our findings show that SIVQ has the potential to be a useful tool in surgical pathologists' toolkits when optimized to aid detection of such a highly variable disease, but the case is an excellent example for how the same approach might be applied to a variety of clinical areas," says Ulysses Balis, M.D., director of the division of pathology informatics at U-M and the paper's senior author.
Balis led the software's design at U-M along with Hipp and former informatics fellow Jerome Cheng, M.D.
Unlike other pattern recognition software, SIVQ bases its matches on a set of concentric rings rather than the usual square block. This allows features to be identified no matter how they're rotated or whether they're flipped, as in a mirror.
An example of the program's flexibility was recently demonstrated by Bruce P. Levy, M.D., a research fellow in pathology at Harvard Medical School. Testing the program's utility in a forensic pathology setting, SIVQ was used to calculate the area of bullet wounds and to identify and quantify stippling, which are small scrapes surrounding some gunshot wounds that help to determine the distance from which a gun was fired.
"Being able to use software like SIVQ to analyze forensic images helps to bring the practice of forensic pathology closer to the high-tech fictional world of CSI," Levy says.
Since the computer-aided analysis of micropapillary urothelial carcinoma might contribute to patient care, the group is making all of their primary data freely available to other doctors and researchers at U-M's online digital imaging repository, www.WSIrepository.org.
This paper marks the researchers' 11th SIVQ-related publication, including two editorials. Several others are currently in progress.
###
Resources:
More about SIVQ
http://www.uofmhealth.org/news/sivq_pathology_0200
U-M Department of Pathology
http://www.pathology.med.umich.edu/
Additional authors: Scott Arthur Tomlins, Ph.D., Lakshmi Priya Kunju, M.D., of U-M. James Monaco, Ph.D., Anant Madabhushi, Ph.D., of Rutgers University.
Funding: The research was supported by the Michigan Institute for Clinical & Health Research and U-M Clinical and Translational Sciences Award.
Disclosures: U-M is currently seeking licensing partners to bring this technology to market.
Citation: "Optimization of complex cancer morphology detection using the SIVQ pattern recognition algorithm," Analytical Cellular Pathology, Volume 35, Number 1 / 2012.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 13-Jan-2012[ | E-mail |
Share ] Contact: Ian Demsky
idemsky@umich.edu
734-764-2220
University of Michigan Health System
In bladder cancer test case, new software tool developed at U-M separates malignancy from background tissue
As tissue slides are more routinely digitized to aid interpretation, a software program whose design was led by the University of Michigan Health System is proving its utility.
In a new study, a program known as Spatially Invariant Vector Quantization (SIVQ) was able to separate malignancy from background tissue in digital slides of micropapillary urothelial carcinoma, a type of bladder cancer whose features can vary widely from case to case and that presents diagnostic challenges even for experts.
The findings by U-M and Rutgers University researchers were published online in Analytical Cellular Pathology ahead of print publication.
"Being able to pick out cancer from background tissue is a key test for this type of software tool," says U-M informatics fellow Jason Hipp, M.D., Ph.D., who shares lead authorship of the paper with resident Steven Christopher Smith, M.D., Ph.D. "This is the type of validation that has to happen before digital pathology tools can be widely used in a clinical setting."
To test the software's ability to identify cancer in a digital slide, a group of human pathologists first pinpointed the cancer the old fashioned way, by hand. Their work was then used as the gold standard for grading the program's results. Researchers then systematically tested which settings within the program produced the most accurate results which can serve as a blueprint for optimizing the software to detect other types of cancer and disease.
Diagnosing cancer and other pathologies from tissue slides has always been part science and part art. Pathologists pore over samples looking for certain structural anomalies or counting microscopic features.
But different pathologists or even the same pathologist at different times may come to different conclusions based on a number of factors, including whether a slide is viewed at high or low magnification, or even whether the pathologist is fatigued from examining dozens of other slides that day, the researchers say.
Digital tools like SIVQ can help pathologists to quickly, accurately and efficiently identify features on a slide with just a few clicks; to quickly calculate the area of an irregularly shaped feature; or to eliminate the slow and painstaking tallying of tiny elements.
Still, the authors stress, the program isn't intended to replace the skill and art of human pathologists, but to provide an additional resource.
"Not only do our findings show that SIVQ has the potential to be a useful tool in surgical pathologists' toolkits when optimized to aid detection of such a highly variable disease, but the case is an excellent example for how the same approach might be applied to a variety of clinical areas," says Ulysses Balis, M.D., director of the division of pathology informatics at U-M and the paper's senior author.
Balis led the software's design at U-M along with Hipp and former informatics fellow Jerome Cheng, M.D.
Unlike other pattern recognition software, SIVQ bases its matches on a set of concentric rings rather than the usual square block. This allows features to be identified no matter how they're rotated or whether they're flipped, as in a mirror.
An example of the program's flexibility was recently demonstrated by Bruce P. Levy, M.D., a research fellow in pathology at Harvard Medical School. Testing the program's utility in a forensic pathology setting, SIVQ was used to calculate the area of bullet wounds and to identify and quantify stippling, which are small scrapes surrounding some gunshot wounds that help to determine the distance from which a gun was fired.
"Being able to use software like SIVQ to analyze forensic images helps to bring the practice of forensic pathology closer to the high-tech fictional world of CSI," Levy says.
Since the computer-aided analysis of micropapillary urothelial carcinoma might contribute to patient care, the group is making all of their primary data freely available to other doctors and researchers at U-M's online digital imaging repository, www.WSIrepository.org.
This paper marks the researchers' 11th SIVQ-related publication, including two editorials. Several others are currently in progress.
###
Resources:
More about SIVQ
http://www.uofmhealth.org/news/sivq_pathology_0200
U-M Department of Pathology
http://www.pathology.med.umich.edu/
Additional authors: Scott Arthur Tomlins, Ph.D., Lakshmi Priya Kunju, M.D., of U-M. James Monaco, Ph.D., Anant Madabhushi, Ph.D., of Rutgers University.
Funding: The research was supported by the Michigan Institute for Clinical & Health Research and U-M Clinical and Translational Sciences Award.
Disclosures: U-M is currently seeking licensing partners to bring this technology to market.
Citation: "Optimization of complex cancer morphology detection using the SIVQ pattern recognition algorithm," Analytical Cellular Pathology, Volume 35, Number 1 / 2012.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-01/uomh-sfa011312.php
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Mets' Santana not sure about opening day
By RONALD BLUM
updated 5:04 p.m. ET Jan. 12, 2012
NEW YORK - Sixteen months after shoulder surgery, Johan Santana hopes to be back on the mound for the New York Mets when the season starts. He just doesn't want to commit to it.
"It's going to be tough for me to guess, because I don't know how I'm going to be in two months," the injured left-hander said Thursday.
The two-time Cy Young Award winner hasn't pitched in the major leagues since Sept. 2, 2010, 12 days before an operation repaired a torn anterior capsule.
He made three minor league rehabilitation outings totaling eight innings last July 28, Sept. 3 and Sept. 9 and resumed throwing on flat ground about three weeks ago.
He threw from 90 feet about 25 times Thursday and planned to increase the distance to 110 feet in his next session. His goal is to be ready for bullpen sessions when the Mets start spring training workouts on Feb. 22.
"I'm very excited to be here right now. It's been a long process for me," he said. "I cannot tell you what's going to happen in five, six weeks from now because I'd be lying to you. I've got to go one day at a time."
When New York takes the field for its opener against Atlanta on April 5, the Mets roster will be much changed from 2010. All-Stars Jose Reyes, Carlos Beltran and Francisco Rodriguez have departed, and the payroll has been cut by about $50 million as the Mets deal with the fallout of three straight losing seasons and the financial troubles caused by the Bernard Madoff Ponzi scheme.
Reyes left last month for a $106 million, six-year contract with the NL East rival Miami Marlins.
"It's kind of tough to see him go, but that's part of the game," Santana said. "It's going to be a learning process for a lot of guys here, but at the same time, we're going to compete, we're going to play and we're going to have fun, because I think that's the key to being successful."
Santana is commuting between his home in Fort Myers, Fla., and the Mets' training camp across the state in Port St. Lucie. He says his arm feels fine but he won't be able to judge if he's back to his old self until after the stresses of repeated bullpens and spring training outings.
"At the end of my rehab last year I felt good. But I also knew, they told me, the doctors told me, that rest was part of my rehab and then I have to shut everything down," he said. "Now we have to start all over again and see where we're at."
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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More newsGetty ImagesNats?continue to pursue Fielder
HBT: Despite an earlier report saying the Nats weren't after the slugger, Prince Fielder is still very much a target for the team, as owners met with agent Scott Boras on Wednesday.
MLB gives Selig 2-year extension
PARADISE VALLEY, Arizona (AP) -Baseball Commissioner Bud Selig has been given a two-year contract extension through the 2014 season.
Source: http://nbcsports.msnbc.com/id/45977429/ns/sports-baseball/
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B-list celebs hit the high seas
Ray Tamarra / Getty Images Contributor
Kate Gosselin will host a cruise in August aboard Royal Caribbean's Allure of the Seas.
By Rob Lovitt, msnbc.com contributor
Can?t get your fill of celebrity culture from your TV or Twitter feed? Not a problem.
Sign up for the just-announced Kate Gosselin cruise?and you can sail away with the two-time reality-TV star ("Jon & Kate Plus 8," "Kate Plus 8"), former ?Dancing with the Stars? competitor and celebrity blogger for CouponCabin.com.
B-list celebrities don?t die, it seems, they just find new ways to market themselves.
?Part of it is a realization that celebrities as we have traditionally thought of them were folks who weren?t accessible to us,? said Carla Santos, associate professor of tourism management at the University of Illinois at Urbana-Champaign.
?You?re never going to be on a cruise with Brad Pitt or Angelina Jolie so the next best thing is someone who?s had a few minutes of fame,? she told msnbc.com.
Consider some of the other less-than-A-list cruises currently available:
- The Weezer Cruise: Almost two decades after hitting the charts, the popular ?90s band will be sailing from Miami to Cozumel on the Carnival Destiny, Jan. 19?23. Everybody sing: Ooo-wee-oo, I look just like Captain Stubing, oh-oh, and you?re Julie McCoy ...
- The Star Trek Cruise: Quick, can you name the characters played by John Billingsley, Denise Crosby and Garrett Wang on the various iterations of "Star Trek?" Neither can we but, apparently, they?re the featured celebs on a Celebrity cruise that will boldly go, well, to the Western Caribbean. Alas, dates are not currently available, perhaps due to a fluctuation of the time-space continuum, the machinations of the Borg or a general lack of interest.
- Love Letter Cruise: You?ve heard him on land, says the website, you?ve heard him on the radio but you?ve never heard him at sea. Who?s him? That would be R. Kelly, who?ll be crooning his way from Miami to the Bahamas on the Carnival Destiny, Oct. 1??6. Think ?Bump ?N Grind? meets the motion of the ocean.
Live Poll
What themed cruise would you rather board?
173126
Kate Gosselin
6%
173127
Weezer
11%
173128
Star Trek
12%
173129
Love Letter
1%
173130
I'd rather go to work
71%
VoteTotal Votes: 487
Gosselin, of course, adds a new twist to the concept of celeb-hosted cruises as her accomplishments basically amount to achieving fame for being famous. Still, if you want to meet Kate in person, have your photo taken with Kate and receive a personalized gift from Kate, well, mark your calendar for Aug. 12?19 when the Allure of the Seas will set sail for the Western Caribbean.
In the meantime, consider the fact that the close quarters of a cruise ship can be both a blessing and a curse, especially when it comes to mingling with someone best known for controlling behavior, public meltdowns and terrible dancing.
?The cruise setting is interesting,? said Santos. ?It works perfectly for what they?re trying to create, which is closeness and the ability to rub elbows with these folks.?
On the other hand, she added, ?You can?t leave unless you decide to jump ship.?
For some reason, the vision of a Kim Kardashian cruise just popped into our heads.
More stories you might like:
Rob Lovitt is a longtime travel writer who still believes the journey is as important as the destination. Follow him at Twitter.
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Source: http://todaytravel.today.msnbc.msn.com/_news/2012/01/11/10120051-b-list-celebs-hit-the-high-seas
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Saturday, 14 January 2012
Perfectly spherical gold nanodroplets produced with the smallest-ever nanojets
ScienceDaily (Jan. 13, 2012) ? KU Leuven researcher Ventsislav Valev and an international team of scientists have developed a new method for optical manipulation of matter at the nanoscale. Using 'plasmonic hotspots' -- regions with electric current that heat up very locally -- gold nanostructures can be melted and made to produce the smallest nanojets ever observed. The tiny gold nanodroplets formed in the nanojets, are perfectly spherical, which makes them interesting for applications in medicine.
The 'backjet' phenomenon on which the method turns can be compared to a pebble being dropped into water. Tightly focused ultrafast laser pulses carry sufficient energy to locally melt the surface of a gold film. When a laser pulse of light hits the film, a nanoscale backjet -- a nanojet -- of molten gold surges upward.
As the name suggests, nanojets on the surface of a homogeneous gold film are incredibly small, their size being determined by the distribution of energy in the light pulse. This distribution of energy is in turn dependent on the wavelength of light. Initially, scientists anticipated that nanojets could not be significantly smaller than the wavelength of light. In this study however, Ventsislav Valev and his colleagues show that nanojets can in fact be made much smaller with the help of 'plasmonic hotspots'.
Plasmonic hotspots are regions on the surface of metal nanostructures where light causes very strong oscillation of the electrons. Because electron oscillations constitute an electric current and because electric currents heat up the material the same way an electric stove heats up in the kitchen, the plasmonic hotspots are extremely hot. So hot that they can melt the gold in a spot much smaller than the wavelength of light. Dr. Valev and his colleagues were successfully able to demonstrate that this tiny little pool of molten gold can give rise to the smallest nanojets ever observed.
The gold nanodroplets propelled upward by the nanojets solidify in flight, producing perfectly spherical nanoparticles. These gold nanodroplets can be collected and used for medical applications including cancer treatment. The nanoparticles can be attached to molecules and injected in the blood. Once the molecules attach to cancer cells, light can be used to heat up the gold nanodroplets and destroy the cancer cells. Currently, the gold nanoparticles used in medications are chemically synthesised. These chemically synthesised gold nanoparticles have an unavoidably granular aspect. Conversely, gold nanodroplets created by the plasmonic nanojet method detailed by Dr. Valev and his colleagues are perfectly spherical, ensuring a better efficiency.
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Story Source:
The above story is reprinted from materials provided by Katholieke Universiteit Leuven, via AlphaGalileo.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Ventsislav K. Valev, Denitza Denkova, Xuezhi Zheng, Arseniy I. Kuznetsov, Carsten Reinhardt, Boris N. Chichkov, Gichka Tsutsumanova, Edward J. Osley, Veselin Petkov, Ben De Clercq, Alejandro V. Silhanek, Yogesh Jeyaram, Vladimir Volskiy, Paul A. Warburton, Guy A. E. Vandenbosch, Stoyan Russev, Oleg A. Aktsipetrov, Marcel Ameloot, Victor V. Moshchalkov, Thierry Verbiest. Plasmon-Enhanced Sub-Wavelength Laser Ablation: Plasmonic Nanojets. Advanced Materials, 2012; DOI: 10.1002/adma.201103807
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
Source: http://www.sciencedaily.com/releases/2012/01/120113205444.htm
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